Tokyo stocks closed marginally lower Wednesday in choppy trade as investors opted to take profits ahead of potentially tricky U.S.-Japan trade talks the following day.

The 225-issue Nikkei Stock Average edged down 18.43 points, or 0.08 percent, from Tuesday to close the day at 22,644.31.

The broader Topix index of all First Section issues on the Tokyo Stock Exchange, meanwhile, lost 1.34 points, or 0.08 percent, to finish at 1,744.71.

Oil and coal product, and rubber product issues comprised those that declined the most, while information and communication, and machinery issues led those that gained the most by the close of play.