Latest News
Chinese scientists produce genetically-enhanced human vascular cells
Last Updated: 2019-01-18 09:18 | Xinhua
 Save  Print   E-mail

Chinese scientists produced the world's first genetically-engineered human blood vessel cells, providing a promising option for therapeutic use.

The study published on Thursday in the journal Cell Stem Cell showed that human vascular cell function can be enhanced by editing a single longevity-related gene.

Scientists from the Institute of Biophysics of the Chinese Academy of Sciences (CAS), Peking University and the Institute of Zoology of CAS targeted a gene called FOXO3, an important regulator to delay cellular aging, resist stresses and enhance cardiovascular balance.

Compared with those of wildtype cells, the genetically-enhanced vascular cells could efficiently promote vascular repair and regeneration, increasing resistance to oxygen-causing injury, according to the study.

The technique can also resist the cells' transformation into tumors. The risk of tumor transformation used to be a major concern for the application of the gene-editing technology.

The researchers tested it in a mouse model with blood-shortage or ischemic injury and found that those cells promoted vascular regeneration and resisted tumor transformation both in vitro and in vivo.

They expected to use gene-editing strategies in the future to produce high-quality, safe human vascular cell grafts in a large-scale and standardized manner.

Share to 
0
Related Articles:
BACK TO TOP
  • Sports
  • Soccer
  • Basketball
  • Tennis
  • Formula One
  • Athletics
  • Others
  • Entertainment
  • Celebrity
  • Movie & TV
  • Music
  • Theater & Arts
  • Fashion
  • Beauty Pageant
Edition:
Link:    
About CE.cn | About the Economic Daily | Contact us
Copyright 2003-2015 China Economic Net. All right reserved
Chinese scientists produce genetically-enhanced human vascular cells
Source:Xinhua | 2019-01-18 09:18
Share to 
0