A fire broke out at the John F. Kennedy Library a few miles (kilometers) away. The police commissioner said it may have been caused by an incendiary device but it didn't appear to be related to the bombings.

"There are people who are really, really bloody," said Laura McLean, a runner from Toronto, who was in the medical tent being treated for dehydration when she was pulled out to make room for victims.

About four hours into the race and two hours after the men's winner crossed the line, there was a loud explosion on the north side of Boylston Street, just before the photo bridge that marks the finish line. Another explosion could be heard a few seconds later.

By that point, more than 17,000 of the runners had finished the race, but thousands of others were farther back along the course.

The Boston Police Department said two people were killed. Hospitals reported at least 73 injured, at least eight of them critically.

A senior US intelligence official said the two other explosive devices found nearby were being dismantled. The official spoke on condition of anonymity because he was not authorized to discuss the findings publicly.

A woman who was a few feet from the second bomb, Brighid Wall, 35, of Duxbury, said that when it exploded, runners and spectators froze, unsure of what to do. Her husband threw their children to the ground, lay on top of them and another man lay on top of them and said, "Don't get up, don't get up."

After a minute or so without another explosion, Wall said, she and her family headed to a Starbucks and out the back door through an alley. Around them, the windows off the bars and restaurants were blown out.

She said she saw six to eight people bleeding profusely, including one man who was kneeling, dazed, with blood coming down his head. Another person was on the ground covered in blood and not moving.

"My ears are zinging. Their ears are zinging. It was so forceful. It knocked us to the ground."

Competitors and race volunteers were crying as they fled the chaos. Authorities went onto the course to carry away the injured while race stragglers were rerouted away from the smoking site.

Roupen Bastajian, a 35-year-old state trooper from neighboring Rhode Island, had just finished the race when they put the heat blanket wrap on him and he heard the blasts.

"I started running toward the blast. And there were people all over the floor," he said. "We started grabbing tourniquets and started tying legs. A lot of people amputated. ... At least 25 to 30 people have at least one leg missing, or an ankle missing, or two legs missing."

Smoke rose from the blasts, fluttering through the national flags lining the route. Blood stained the pavement in the popular shopping and tourist area known as the Back Bay.

Cherie Falgoust was waiting for her husband, who was running the race.

"I was expecting my husband any minute," she said. "I don't know what this building is ... it just blew. Just a big bomb, a loud boom, and then glass everywhere. Something hit my head. I don't know what it was. I just ducked."

Runners who had not finished the race were diverted straight down Commonwealth Avenue and into a family meeting area, according to an emergency plan that had been in place.

In Washington, shortly after the explosions, the presidential Secret Service shut down Pennsylvania Avenue outside the White House, cordoning off the area with yellow police tape. Several Secret Service patrol cars also blocked off the entry points to the road.

Attorney General Eric Holder directed the full resources of the Justice Department be deployed to investigate and a department official said Holder has spoken with FBI Director Robert Mueller. The official said the US attorney for Massachusetts's office was coordinating the Justice Department's response with the FBI and other federal, state and local law enforcement authorities.

Cities worldwide stepped up security following the explosions.

In Britain, police said they were reviewing security plans for Sunday's London Marathon, the next major international marathon. Thousands of people compete in the London Marathon every year, thronging the city's streets. London is also considered a top target for international terrorists.

A London Metropolitan Police spokesman confirmed Monday that police are working with marathon officials to review security plans for Sunday's event. The London race's chief executive, Nick Bitel, expressed shock and sadness about the situation in Boston, saying "it is a very sad day for athletics and for our friends in marathon running."

In New York City, police spokesman Paul Browne said that critical response teams are deployed around the city. Officials were stepping up security at hotels and other prominent locations.

Police at three major Los Angeles area airports, including Los Angeles International Airport, were in a "heightened state of vigilance," with increased patrols to make it visible that more police were on duty Monday, said Chief of Airport Police Patrick Gannon.

Race day got started with 26 seconds of silence in honor of the victims of the December school massacre in Connecticut. A little more than 2 hours later, the lead runners passed the Mile 26 marker, which was decorated with the Newtown, Connecticut, seal and dedicated to the memory of those killed there.

Boston Athletic Association president Joanne Flaminio previously said there was "special significance" to the fact that the race is 26.2 miles long and 26 people died at Sandy Hook Elementary school.

The annual marathon attracts more than 500,000 spectators. It takes place on Patriot's Day, a state holiday that celebrates the evacuation of Boston by the British in the American Revolution.

Spectator Cherie Falgoust was waiting for her husband, who was running the race.

"I was expecting my husband any minute," she said. "I don't know what this building is ... it just blew. Just a big bomb, a loud boom, and then glass everywhere. Something hit my head. I don't know what it was. I just ducked."

Associated Press writers Jimmy Golen, Jay Lindsay, Steve LeBlanc and Meghan Barr in Boston and Lara Jakes and Eileen Sullivan in Washington contributed to this report.